In recent years, the increased number of method transfer failures has led to greater transfer scrutiny by industry and regulators. And for good reason. Simple paper transfers between sending and receiving units and provision of ambiguous information are widely regarded as insufficient. These outdated practices are now being superseded by more proactive approaches to support successful method transfer, including the provision of method transfer packages and improved lab-to-lab communication1. Indeed, it was a decade ago that Nethercote, et al2 described the benefits of Quality-by-Design based method development with the goal of creating more robust analytical procedures. Despite these advances, however, there are still situations where methods that come into the receiving lab are poorly understood, or insufficient information is available. Even with the implementation of pharmacopoeial methods, or well-understood robust methods, predicting problems can be challenging, and many only show up over time.